Scientific Publications

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Delaney C, Milano F, Cicconi L, Othus M, Becker PS, Sandhu V, Nicoud I, Dahlberg A, Bernstein IDB, Appelbaum FR, Estey EH. Infusion of a non-HLA-matched ex-vivo expanded cord blood progenitor cell product after intensive acute myeloid leukaemia chemotherapy: a phase 1 trial. Lancet Haematol. 2016 Jul;3(7):e330-9. Epub 2016 Jun 7

Milano F, Gooley T, Wood B, Woolfrey A, Flowers ME, Doney K, Witherspoon R, Mielcarek M, Deeg JH, Sorror M, Dahlberg A, Sandmaier BM,Salit R, Petersdorf E, Appelbaum FR, Delaney C. Cord-Blood Transplantation in Patients with Minimal Residual Disease. N Engl J Med. 2016 Sep 8;375(10):944-53.

Li J, Blake J, Delaney C. Identificationof CD137+ IFN-g- CD4+ Alloreactive T Cells Post Myeloablative Double Cord BloodTransplant: A Synergistic Role in the Graft Versus Graft Interaction. ASBMT AnnualMeeting, San Diego, CA February 2015.

Dahlberg A,Milano F, Delaney C. Infusion of ex vivo expanded cord blood progenitor cells is associated with reduced hospital daysand utilization of opiate infusion and total parental nutrition in pediatricpatients receiving myeloablative cord blood transplantation. ASBMT AnnualMeeting, San Diego, CA February 2015.

Milano F, Heimfeld S, Riffkin I, Nicoud I, Appelbaum FR, Bernstein ID, Delaney C. Infusion of a Non HLA-Matched Off-the-Shelf Ex Vivo Expanded Cord Blood Progenitor Cell Product following Myeloablative Cord Blood Transplantation is Safe, Decreases the Time to Hematopoietic Recovery, and Results in Excellent Overall Survival. ASH Annual Meeting, San Francisco, CA, December 2014

Li J, Milano F, Blake JM, Oliver DC, Nicoud I, Heimfeld S, Delaney C. Real-Time Immunophenotyping of Peripheral Blood Early Post Myeloablative Cord BloodTransplant Can Identify Patients at Risk for Primary Graft Failure. ASH Annual Meeting, San Francisco, CA, December 2014

Summers C, Milano F, Gooley TA, Dahlberg A, Delaney C. Infusion of ExVivo Expanded Cord Blood Progenitor Cells Reduces the Risk of Bacteremia after Myeloablative Cord Blood Transplant. ASH Annual Meeting, San Francisco, CA, December 2014

Merriam FV, Nicoud I, Milano F, Li J, Heimfeld S, Delaney C. Notch-Expanded Murine Hematopoietic Progenitor Cells Can Induce Immune Tolerance in Mismatched Recipients. ASH Annual Meeting, San Francisco, CA, December 2014

Milano F, Heimfeld S, Riffkin IB, Nicoud I, Appelbaum FR, Bernstein ID, Delaney C. Infusion of a Non HLA-Matched Off-the-Shelf Ex Vivo Expanded Cord Blood Progenitor Cell Product Following Myeloablative Cord Blood Transplantation Is Safe, Decreases the Time to Hematopoietic Recovery, and Results in Excellent Overall Survival. ASH Annual Meeting, San Francisco, CA, December 2014

Gardner R,Summers C, Weber D, Jensen MC, Delaney C. Lentiviral Transduction Of Notch Ligand Expanded Cord Blood HSC's To Express a CD19-Specific CARGenerates NK and Myeloid Progeny With Antitumor Activity. ASH Annual Meeting, New Orleans, LA, December 2013

Delaney C, Milano F, Heimfeld S, Nicoud I, Bernstein ID. Infusion of non-HLA matched, Off-the-Shelf Ex Vivo Expanded Cord Blood Progenitor Cells in Patients Undergoing Myeloablative Cord BloodTransplantation is Safe and Decreases the Time to Neutrophil Recovery. ASBMT/CIBMTR Tandem Meetings, February, 2012.

Delaney C, Becker PS, Milano F, Nicoud IB, Heimfeld S, Riffkin I, Papermaster A, Appelbaum FR, Bernstein ID, Estey EH. Infusion of 'off-the-shelf' third party ex vivo expanded cord blood progenitor cells as supportive carefollowing clofarabine with high dose cytarabine and granulocytecolony-stimulating factor priming for the treatment of AML. ASH Annual Meeting, December, 2011.

Milano F, Heimfeld S, Gooley T, Jinneman J, Nicoud I, Delaney C. Correlation of Infused CD3(+)CD8(+) Cells with Single Donor Dominance after Double-Unit Cord Blood Transplantation. Biol Blood Marrow Transplant 2013 Jan: 19(1):156-60.

Newell LF, Milano F, Nicoud IB, Pereira A, Gooley TA, Heimfeld S, Delaney C. Early CD3 peripheral blood chimerism predicts the long-term engrafting unit following myeloablative double cord blood transplantation. BBMT. 2012 Aug;18(8):1243-9.

Gutman JA, Turtle CJ, Manley TJ, Heimfeld S, Bernstein ID, Riddell SR, Delaney C. Single-unit Dominance after Double-Unit Umbilical Cord Blood Transplantation Coincides with a Specific CD8+ T-Cell Response Against theNonengrafted Unit (Plenary Paper) Bood 2010 Jan 28;115(4):757-65.

Brustein C, Gutman J, Weisdorf C, Woolfrey A, DeFor T, Gooley T, Verneris M, Appelbaum F, Wagner J, Delaney C. Allogeneic Hematopoietic Cell Transplantation for Hematolotic Malignancy:Relative Risks and Benefirs of Double Umbilical CordBlood. Blood 2010 Nov 25:(116922):4693-9.

Delaney C, Heimfeld S,Brashem-Stein C, Voorhies H, Manger R and Bernstein ID. Notch-mediated expansion of human cord blood progenitor cells capableof rapid myeloid reconstitution. Nature Medicine, 2010 Feb;16(2):232-6.

Dahlberg A, Woo S, Delaney C, Boyle P, Gnirke A, Bock C, Bernstein BE, Meissner A, Gottardo R, Bernstein ID. Notch-mediated expansion of cord blood progenitors: maintenance of transcriptional and epigenetic fidelity. Leukemia. 2015 Sep; 29(9):1948-51

Hadland BK, Varnum-Finney B, Poulos MG, Moon RT, Butler JM, Rafii S, Bernstein ID. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derivedhematopoietic stem cells. J Clin Invest. 2015 May; 125(5):2032-45.

Dahlberg A, Brasheim-Stein C, Delaney C, Bernstein ID. Enhanced Generation of Cord Blood Hematopoietic Stem and Progenitor Cells by Culture with Stem Regenin1 and Delta1(ext-IgG). Leukemia 2014 Oct 28 (10):2097-101.

Blake JM, Nicoud IB, Weber D,Voorhies H, Guthrie KA, Heimfeld S, Delaney C. Improved immunomagnetic enrichment of CD34 (+) cells from umbilicalcord blood using the CliniMACS cell separation system. Cytotherapy. 2012 Aug; 14(7):818-22.

Bernstein I, Delaney C. Engineering Stem Cell Expansion. Cell Stem Cell. 10, 113 (2012).

Dahlberg A, Delaney C, Bernstein ID. Ex Vivo Expansion of Human Hematopoietic Stem and Progenitor Cells. Blood, 2011 Jun 9; 117(23):6083-90.

Varnum-Finney B, Halasz LM, Sun M, Gridley T, Radtke F, Bernstein ID. Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest. 2011 Mar;121(3):1207-16.

Varnum-Finney B,Dallas MH, Kato K, Bernstein ID. Notchtarget Hes5 ensures appropriate Notch induced T- versus B-cell choices in thethymus. Blood. 2008 Mar 1;111(5):2615-20.

Dallas MH, Varnum-Finney B, Martin PJ, Bernstein ID. Enhanced T-cell reconstitution byhematopoietic progenitors expanded ex vivo using the Notch ligand Delta1 Blood. 2007 Apr 15;109(8):3579-87.

Aoyama K, Delaney C,Varnum-Finney B, Kohn AD, Moon RT, Bernstein ID. The interaction of the Wnt and Notch pathways modulates natural killerversus T cell differentiation. Stem Cells. 2007 Oct; 25(10):2488-97.

Delaney C, Varnum-Finney B,Aoyama K, Brashem-Stein C, Bernstein ID. Dose-dependent effects of the Notch ligand Delta1 on marrow repopulating ability of cord blood cells. Blood. 106(8):2693-9, Oct 2005.

Dallas MH, Varnum-Finney B, Delaney C, Kato K, Bernstein ID. Density of the Notchligand Delta1 determines generation of B and T cell precursors fromhematopoietic stem cells. J Exp Med. 201(9):1361-6, 2005

Varnum-Finney B,Brashem-Stein C, Bernstein ID. Combined effects of Notch signaling andcytokines induce a multiple log increase in precursors with lymphoid andmyeloid reconstituting ability. Blood, 101: 1784-1789, 2003.

Ohishi K1, Varnum-Finney B, Bernstein ID. Delta-1 enhances marrow and thymusrepopulating ability of human CD34(+) CD38(-) cordblood cells. J Clin Invest. 2002 Oct;110(8):1165-74.

Ohishi K1, Varnum-Finney B, Serda RE, Anasetti C, Bernstein ID. The Notch ligand, Delta-1, inhibits the differentiation of monocytesinto macrophages but permits their differentiation into dendritic cells. Blood. 2001 Sep 1;98(5):1402-7.

Ohishi K1, Varnum-Finney B, Flowers D, Anasetti C, Myerson D, Bernstein ID. Monocytes express high amounts of Notch and undergo cytokine specificapoptosis following interaction with the Notch ligand, Delta-1. Blood. 2000May 1;95(9):2847-54.

Varnum-Finney B, Wu L,Yu M, Brashem-Stein C, Staats S, Flowers D, Griffin JD, Bernstein ID. Immobilization of Notch ligand Delta-1 is required for induction of Notch signaling. J Cell Sci 2000 113:4313-4318.

Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S,Pear WS, and Bernstein ID. Pluripotent, ctyokine dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nature Med6:1278-1281, 2000.

Varnum-Finney B, Purton LE, Yu M, Brashem-Stein C, Flowers D, Staats S, Moore KA, Le Roux I, Mann R, Gray G, Artavanis-Tsakonas S, Bernstein ID. The Notch ligand,Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood. 1998 Jun 1;91(11):4084-91.

Milner LA, Kopan R, Martin DI, Bernstein ID. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors. Blood. 1994 Apr 15;83(8):2057-62.