Our Science

Our universal donor therapies target hematopoietic recovery and chemotherapy induced neutropenia and are being extended to treat a range of other medical indications.

The science behind umbilical cord blood transplants

See how researchers are making the leap from basic science to new treatments.

Hematopoietic Stem/Progenitor Cell Expansion

During hematopoietic development, the progeny of pluripotent stem cells progressively lose their proliferative potential and capacity for self-renewal, and display greater commitment to a given differentiation pathway.

Clinical Application

The first clinical trial using Notch-mediated ex vivo expanded cord blood HSPC was initiated by Dr. Delaney in 2006 in the myeloablative double cord blood transplant setting.

Latest scientific publications

Delaney C, Milano F, Cicconi L, Othus M, Becker PS, Sandhu V, Nicoud I, Dahlberg A, Bernstein IDB, Appelbaum FR, Estey EH. Infusion of a non-HLA-matched ex-vivo expanded cord blood progenitor cell product after intensive acute myeloid leukaemia chemotherapy: a phase 1 trial. Lancet Haematol. 2016 Jul;3(7):e330-9. Epub 2016 Jun 7

Milano F, Gooley T, Wood B, Woolfrey A, Flowers ME, Doney K, Witherspoon R, Mielcarek M, Deeg JH, Sorror M, Dahlberg A, Sandmaier BM,Salit R, Petersdorf E, Appelbaum FR, Delaney C. Cord-Blood Transplantation in Patients with Minimal Residual Disease. N Engl J Med. 2016 Sep 8;375(10):944-53.

Li J, Blake J, Delaney C. Identificationof CD137+ IFN-g- CD4+ Alloreactive T Cells Post Myeloablative Double Cord BloodTransplant: A Synergistic Role in the Graft Versus Graft Interaction. ASBMT AnnualMeeting, San Diego, CA February 2015.

Dahlberg A,Milano F, Delaney C. Infusion of ex vivo expanded cord blood progenitor cells is associated with reduced hospital daysand utilization of opiate infusion and total parental nutrition in pediatricpatients receiving myeloablative cord blood transplantation. ASBMT AnnualMeeting, San Diego, CA February 2015.